Why NAD+ matters
Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme present in every living cell. It plays a central role in cellular energy production by facilitating redox reactions, especially within the mitochondria—the body’s energy factories.
As we age, NAD+ levels naturally decline. This drop is linked to reduced mitochondrial function, slower cellular repair, and an increased susceptibility to metabolic stress. Low NAD+ has also been associated with cognitive decline, fatigue, and metabolic dysfunction.
Cellular was developed to support the body’s natural NAD+ levels and optimize its role in metabolism, energy production, and cellular defense.
The formula, decoded
NAD+
Cellular delivers bioavailable NAD+ directly—offering an alternative to precursors like NMN or NR, which require several conversion steps before becoming NAD+ within the cell. Direct supplementation provides the building block for mitochondrial energy and sirtuin activation, supporting healthy aging and cellular repair.†
NAD+ also supports:
- DNA repair and genomic stability
- Healthy inflammation modulation
- Metabolic efficiency
- Cognitive performance and resilience to neurodegeneration
Quercetin
A plant-based flavonoid, quercetin acts as a natural senolytic—targeting and helping clear out senescent (“zombie”) cells that can accumulate with age and contribute to systemic inflammation. But its role in this formula is even more strategic.
Quercetin also functions as a CD38 inhibitor, reducing the activity of an enzyme that depletes NAD+. By slowing NAD+ degradation, it helps preserve and extend the availability of NAD+ in the body.
Resveratrol
Resveratrol is a polyphenol best known for its ability to activate sirtuins, a class of proteins that regulate mitochondrial health, DNA repair, and inflammation—all processes deeply tied to longevity. Its effects complement NAD+ by enhancing the cellular pathways that NAD+ fuels.
Additionally, resveratrol may support:
- Cardiovascular function
- Glucose metabolism
- Cognitive clarity
- Oxidative stress resilience
The synergy matters
NAD+ does not work in isolation—its availability and impact are directly shaped by other molecules that either preserve, amplify, or direct its use within the cell.
Many supplements focus on just one part of this equation. Cellular includes three distinct but complementary components that together form a full-cycle NAD+ support system:
1. NAD+ — The Coenzyme at the Core
NAD+ is the central molecule that makes cellular energy production (via the Krebs cycle and electron transport chain) possible. It also acts as a substrate for enzymes involved in:
- DNA repair (via PARPs)
- Inflammation regulation
- Circadian rhythm maintenance
- Sirtuin activation (SIRT1–SIRT7)
However, the body’s NAD+ stores are limited—and under stress or with age, they’re depleted faster than they’re rebuilt. Supplementing with NAD+ helps directly replenish intracellular levels without depending on upstream conversion pathways.
2. Quercetin — CD38 Inhibition + Cellular Senolytic Action
CD38 is an NAD+-consuming enzyme that increases with age and chronic inflammation. It's considered one of the major drivers of age-related NAD+ decline. Quercetin has been shown in preclinical models to inhibit CD38, slowing the breakdown of NAD+ and preserving intracellular stores.
Additionally, quercetin is classified as a senolytic—it helps remove senescent cells, which release inflammatory signals and disrupt healthy tissue environments. These cells have been linked to biological aging and tissue dysfunction.
By clearing these cells, quercetin may improve systemic responsiveness to NAD+ and reduce background inflammation that would otherwise increase CD38 expression.
3. Resveratrol — Sirtuin Activation and Mitochondrial Signaling
While NAD+ is required to activate sirtuins, resveratrol acts as a direct activator of SIRT1, mimicking caloric restriction and promoting mitochondrial biogenesis, improved insulin sensitivity, and anti-inflammatory gene expression.
Sirtuins are NAD+-dependent enzymes, meaning they only function when NAD+ is available. Resveratrol ensures these enzymes are primed and responsive, enhancing the downstream benefits of increased NAD+ availability.
The result
A closed-loop system. Rather than supplying NAD+ alone—or relying on the body to convert a precursor—Cellular supports each stage of NAD+ metabolism:
- Input: Direct NAD+ replenishment
- Preservation: Quercetin inhibits NAD+ degradation (via CD38)
- Utilization: Resveratrol supports NAD+-driven pathways via sirtuins
The result is a tightly integrated formula designed to support NAD+ levels, extend its half-life, and optimize its energy-supporting and healthy-aging effects throughout the body.
Studies referenced:
The Role of NAD+ in Regenerative Medicine
Modulation of Sirtuins to address aging related disorders through the use of selected phytochemicals
† Individual absorption and tissue uptake may vary.